At Mr Vitamins, our team of qualified naturopaths, nutritionists, and wellness professionals carefully review supplements to recommend options that support the body during stressful times.

Stress is a normal part of life, but too much stress over time can affect your energy, mood, sleep, and overall wellbeing. When the body is under constant pressure, it uses more nutrients and may struggle to stay balanced.

These practitioner-recommended formulas are designed to help with stress management, nervous system support, mood balance, and daily energy.

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Below are four stress supplements recommended by practitioner Christina Hanley that may help support the body’s natural stress response.

1. Herbs of Gold Activated B Stress
2. Designs for Health TriGandha
3. Fusion Health Stress & Anxiety
4. Eagle Tresos Activated B PluSe[1]

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4 Best Supplements Practitioner Christina Hanley Recommends for Managing Stress

1. Herbs of Gold Activated B Stress

• • Best for: stress-related fatigue & low energy
  • Ingredients: Activated B-vitamins + Holy Basil

 2. Designs for Health TriGandha

• • Best for: calm mind, anxiety & high stress load
  • Ingredients: Triple Ashwagandha (Sensoril®, NooGandha®, Shoden®)

 3. Fusion Health Stress & Anxiety

• • Best for: nervous tension, anxiety & sleep-related stress
  • Ingredient: Ashwagandha, Holy Basil, Polygala, Magnolia bark

 4. Eagle Tresos Activated B PluSe

• • Best for: burnout recovery & long-term stress resilienc
  • Ingredients: Activated B-vitamins + minerals (magnesium, selenium, zinc)

Below is a simple breakdown of ingredients and a quick comparison of how each supplement works to support the body and mind.

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4 Top Stress Relief Supplements

If you're looking for support during times of stress, these supplements offer a mix of activated B vitamins, adaptogenic herbs and practitioner-grade nutrient formulas. The table below compares the main ingredients, benefits, dosage, pack size and warnings for each option.

Looking for more options? You can also explore our collection of stress support supplements, and magnesium supplements.

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Detailed Product Ingredient Description 

Below is a more detailed description of product indigents and the part the play in reducing stress. 

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1. Herbs of Gold Activated B Stress

What it is: A one-a-day activated B-Vitamin complex with added Holy Basil herbal extract.

It’s designed to relieve symptoms of stress and support energy levels[1].

Key Ingredients: 

•  Holy Basil (Ocimum tenuiflorum) - 250 mg of Holixer™
  

Holy basil is a natural herb that helps your body cope with stress. It’s known as an adaptogen, meaning it supports balance when you’re feeling run down or overwhelmed.

Research on a concentrated extract called Holixer™ found that people who took it experienced lower stress levels and better sleep after 8 weeks.

In one study, stress ratings dropped by about 37% compared to 19% with placebo, showing a noticeable calming effect. [2][3]

• B-Complex Vitamins (B1, B2, B3, B5, B6, B9, B12, Biotin)

This formula contains high-strength, ready-to-use forms of key B vitamins, including B1, B2, B3, B5, B6, B9 (folate), B12, and biotin.

B vitamins play an important role in energy production and nervous system health. Because they’re in “activated” forms, your body can absorb and use them more easily.

During times of stress, your need for B vitamins increases, as it helps support the adrenal glands and the production of brain chemicals that regulate mood and focus.

 ●   Vitamin C (250 mg as ascorbic acid)

Vitamin C is a powerful antioxidant that supports your immune system and helps your body cope with stress.

It’s used by the adrenal glands during stressful times and may help reduce feelings of fatigue and physical strain.

This formula provides a generous amount of vitamin C to help protect your cells from damage and support your body when you’re under pressure.

How it helps:

This supplement supports both energy and calm when you’re feeling stressed.

1. 1. 1. B vitamins help turn food into energy and support your nervous system, reducing mental fatigue.
      2. Holy Basil promotes relaxation and helps lower stress levels.
      3. May help you feel more energized, focused, and balanced.

Dosage: 

Adults: Take 1 tablet daily with food, or as directed by a healthcare professional.

Size: Available in 30 or 60 tablet bottles.

Warnings / Precautions:

• • Always read the label and follow directions for use.

  • Contains vitamin B6:

    • Stop taking and consult a healthcare practitioner if you experience tingling, burning or numbness (possible nerve irritation).

  • Vitamin supplements should not replace a balanced diet.

 Always read the label and follow the directions for use. Consult a healthcare professional if symptoms persist.

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 2. Designs for Health 

What it is: A herbal stress support supplement made with three types of ashwagandha extract.

It’s designed to deliver the benefits of this well-known adaptogen, helping support stress, mood, and overall vitality.

Key Ingredients (per capsule):

• Ashwagandha Extracts (650 mg total):

 This product contains three different standardised ashwagandha extracts:

• Sensoril® - 250 mg:

 A patented extract from ashwagandha root and leaf that helps your body manage stress. Sensoril is known for its potent anti-stress and cortisol-lowering effects.

Studies on similar root/leaf extracts have shown significant reduction in chronic stress symptoms even at low doses[8].

By modulating the HPA axis (your body’s stress response system), Sensoril helps reduce anxiety and fatigue and supports adrenal balance.

• NooGandha® - 250 mg:

 A newer, liposomal ashwagandha extract designed for cognitive benefits.

Research on NooGandha has found it can improve aspects of cognition and mood,  such as enhancing short-term memory, focus, and reaction time in healthy adults[9].

It also has been shown to reduce markers of stress in people with high stress[10].

NooGandha helps you feel less stressed but may also help keep your mind sharp under stress.

• Shoden® - 150 mg:

 A concentrated ashwagandha extract that provides reliable active ingredients.

It helps lower stress levels, ease anxiety, support better sleep, and promote a balanced mood. Included for strong, effective stress support.11]

Note: These three extracts provide a wide range of ashwagandha’s active compounds in a strong dose. TriGandha’s focus is 100% ashwagandha in a vegetarian capsule.

How it helps:

TriGandha is designed for people looking to manage stress using the benefits of ashwagandha. This well-researched herb helps balance cortisol (the stress hormone), supporting a calmer mood, better sleep, and steady energy.

This formula combines three types of ashwagandha to provide broad support:

• • Helps reduce stress and support adrenal health
  • Supports focus and mental clarity under pressure
  • Promotes balanced mood and energy

It’s a good choice for people with high stress or anxiety - such as busy professionals or students - who also want cognitive support. The formula contains no stimulants and can be taken alongside other supplements.

Type: Practitioner-only herbal supplement (Ashwagandha blend)

Dosage

• Adults: 1 capsule daily

• Take with food or as directed by a healthcare practitioner.

Size:  60 capsules per bottle - 30 servings

Warnings/ Precautions 

• Practitioner-only product - not sold directly to the public.

• Follow professional guidance for dose.

• Standard herbal precautions:

  • Avoid if allergic to ingredients.

  • Consult practitioner if pregnant, breastfeeding, or on medications.

  • Contains Ashwagandha extracts.

Always read the label and follow the directions for use. Consult a healthcare professional if symptoms persist.

 

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3. Fusion Health Stress & Anxiety

What it is: A herbal stress support formula combining ingredients from traditional Ayurvedic and Chinese medicine.

It promotes calmness while also supporting focus and energy.

Key Ingredients (per tablet):

 

(Fusion uses trademarked, clinically-tested herb extracts where  available, along with traditional herbal preparations.)

• Ashwagandha (Withania somnifera) -187.5 mg of KSM-66® extract (from 1.88 g root).

KSM-66® is a highly concentrated ashwagandha root extract known for its stress-reducing and mood-supporting benefits.

Ashwagandha is an adaptogenic herb that helps the body cope with physical and emotional stress. Research suggests it may help reduce symptoms of stress and anxiety while supporting energy and mental balance[13].

• Holy Basil (Ocimum tenuiflorum) - 300 mg of OciBest® extract (from 3 g whole herb).

Holy basil, also known as Tulsi, is traditionally used to promote calmness and emotional wellbeing.

The OciBest® extract has been shown to help reduce stress and support healthy cortisol levels. In this formula, holy basil adds a calming effect that helps the body stay balanced during stressful periods.

• Polygala (Polygala tenuifolia) - 75 mg extract (from 750 mg root).

Polygala, called Yuan Zhi in traditional Chinese medicine, has long been used to settle the mind and support emotional balance.

Traditionally it has been used to help ease mild anxiety, reduce irritability, and support better sleep.

In this blend, Polygala helps reduce excess nervous energy, irritability and emotional agitation.

•  Magnolia Bark (Magnolia officinalis) - 93.8 mg extract (from 750 mg bark).

Magnolia bark contains natural compounds that may help reduce stress, tension, and anxious feelings.

Research suggests it can support mood and relaxation[14].

In this blend, magnolia helps calm the nervous system and support restful sleep without causing daytime drowsiness. 

• Poria Mushroom (Wolfiporia cocos) - 100 mg extract (from 500 mg sclerotium).

Poria is a traditional Chinese herbal ingredient used to calm the mind and promote relaxation.

It may help reduce stress-related worry and support better sleep.

In this formula, it works alongside the other herbs to promote emotional balance and calmness.

• Citrus Peel (Citrus reticulata) - 75 mg extract (from 750 mg dried peel).

Citrus peel is traditionally used in Chinese medicine to support healthy digestion, particularly when stress affects the stomach.

It may help reduce feelings of indigestion, bloating, or “butterflies” caused by nervous tension, while also providing antioxidant support.

This formula contains no artificial additives and is suitable for vegans. It contains a small amount of lactose from the extraction process.

How it helps:

Helps manage stress in a natural, balanced way.

• • Ashwagandha and holy basil help your body cope with stress and support mood balance
  • Traditional Chinese herbs help calm racing thoughts, irritability, sleep trouble and nervous digestion
  • Promotes relaxation without making you drowsy
  • Supports focus and mental clarity when stress is reduced
    

It may suit people experiencing stress-related issues like poor sleep, tension, or irritability. Taken regularly, it can help you feel calmer, more balanced and better able to handle daily stress.

Dosage

• Adults: 2 tablets twice daily

• Take with food or as professionally prescribed.

Sizes: 60 Tablets & 120 Tablets

Warnings / Precautions

• Do not use during pregnancy or breastfeeding.

• If symptoms persist, consult a health professional.

• Contains:

• Lactose

• Galactose

• Small amount of potassium (~12.9 mg per tablet).

Always read the label and follow the directions for use. Consult a healthcare professional if symptoms persist.

 

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4. Eagle Tresos Activated B PluSe

What it is: A practitioner-strength multivitamin designed to support stress, energy and overall wellbeing.

It provides activated B-vitamins along with key minerals, antioxidants and amino acids to support the body when nutrient needs are increased due to stress or a busy lifestyle.

Key Ingredients (per tablet): Eagle Tresos is packed with vitamins, minerals, and more. Here are the highlights:

• Activated B-Vitamins:

This formula provides a full range of activated B vitamins that are easier for the body to absorb and use.

B vitamins are essential for converting food into energy, supporting brain function, and maintaining a healthy nervous system. During periods of stress, the body uses up these nutrients more quickly.

Supplementing with activated B vitamins helps replenish these levels, supporting steady energy, mental clarity and emotional balance. They also help support adrenal gland function, which plays a key role in how the body responds to stress.[5]

• Antioxidant Vitamins: Vitamin C , Vitamin E and Vitamin A  

This formula includes important antioxidant nutrients that help protect the body from stress-related damage.

Vitamin C supports the immune system and helps the body manage physical stress. Vitamin E helps protect cells from oxidative damage, while Vitamin A supports immune function, skin health and vision.

Together, these antioxidants help maintain resilience and support overall health when the body is under increased stress.

• Minerals and Trace Elements - Magnesium, Zinc, Selenium & more 

Tresos Activated B PluSe also provides a range of essential minerals that support nervous system function, energy production and immune health.

Magnesium helps calm the nervous system and supports muscle relaxation and healthy sleep. Zinc supports brain function, mood and immune defence, while selenium plays an important role in thyroid health, which helps regulate metabolism and energy levels.

These minerals help prevent nutrient deficiencies that may contribute to fatigue, low mood or reduced stress tolerance.

• Amino Acids & Supportive Nutrients - Taurine, Glutamine, Cysteine and Bioflavonoids

This formula also includes amino acids and specialised nutrients that provide additional support for the body during stress.

Taurine helps support brain function and may promote a calm, balanced mood. Glutamine supports gut health and immune function, while cysteine helps the body produce glutathione, one of the body’s key antioxidants.

Additional compounds such as bromelain and citrus bioflavonoids help support circulation and may help reduce inflammation, providing broader support for overall wellbeing.

(Unlike some stress supplements, Tresos Activated B PluSe does not contain herbal adaptogens such as ashwagandha or holy basil. It focuses purely on high-strength nutritional support and is typically recommended by healthcare practitioners.)

How it helps:

This supplement acts like nutritional backup when stress, poor diet or a busy lifestyle drain essential nutrients.

• • Supporting energy levels and reducing fatigue
  • Improving focus and concentration
  • Supporting sleep quality
  • Maintaining mood and stress resilience
  • Supporting immunity during stress
  • Helping prevent burnout by supporting adrenal function
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Dosage

Typical practitioner directions (may vary):

• Adults: 1 tablet daily with food,
  or as directed by a healthcare professional.

Size: 60 Tablets & 150 Tablets

Warnings / Precautions

• Vitamin B supplements may cause temporary urine colour change (bright yellow) due to riboflavin.

• Use caution if:

• Taking other B-vitamin supplements

• Pregnant or breastfeeding (seek practitioner advice).

• Follow practitioner dosing.

Always read the label and follow the directions for use. Consult a healthcare professional if symptoms persist.

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Frequently Asked Questions

What is the best type of supplement for stress? 

The best supplement for stress depends on your needs. Activated B vitamins may suit people experiencing fatigue and low energy, while adaptogenic herbs such as ashwagandha or holy basil may help support a calmer stress response and mood balance.

Are stress supplements safe to take every day? 

Many stress supplements are designed for daily use. However, the right product depends on the ingredients and your individual health needs. Always follow the label directions and seek professional advice if you are pregnant, breastfeeding or taking medication.

Do stress supplements work straight away? 

Some people notice benefits within a few days, particularly with calming herbal formulas. Nutritional formulas such as activated B vitamins may take a few weeks to restore nutrient levels and provide more noticeable improvements in energy and resilience.

Can I take stress supplements with other vitamins or medication? 

Some ingredients may overlap with other supplements or interact with medication. If you are taking prescription medicine, thyroid medication, sedatives or managing a health condition, consult a healthcare professional before starting a new supplement.

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The Takeaway

When it comes to managing stress, there’s no “one-size fits all” solution, it really depends on how you’re feeling and what your body needs right now. 

If you’re run down and needing an energy boost with gentle herbal calm, Activated B Stress can be a great place to start. 

If you are experiencing anxiety, holding tension or going through a busy time in your life, and finding yourself overthinking, perhaps gravitate towards a predominantly herbal formula like Fusion Stress & Anxiety. 

For those wanting a simple yet powerful adaptogen to build stress resilience and support mental clarity under pressure, TriGandha is a standout.

Perhaps you are juggling a lot physically and emotionally, that you just need broad nutritional support to help rebuild and reinforce your stress defences, this is where Tresos Activated B Pluse would be the best option.

Whichever option speaks to you, remember that supplements are there to complement, and not replace the basics. Prioritising sleep, cooking nourishing meals, regular movement and moments of calm will always make the biggest difference.

Think of these formulas as supportive tools, helping you feel steadier, clearer and more resilient as you navigate daily life. As always, follow the directions for use and check in with a healthcare professional if you have any medical conditions or are taking medication.

 

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Resource List 

[1]  Activated B Stress – Herbs of Gold

https://herbsofgold.com.au/products/activated-b-stress?srsltid=AfmBOoqFqMCdXtGDA1ooptg3X5OoSYkPy2g5tteMxiJXy15ahrTE5C35

[2] [3] [6] [7] Frontiers | A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract (HolixerTM) on stress, mood, and sleep in adults experiencing stress

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.965130/full

[4] Multivitamin antioxidant | Tresos Activated B PluSe by Eagle

https://superpharmacyplus.com.au/eagle-tresos-activated-b-pluse-50-tablets/?srsltid=AfmBOop_4tCSuP-iHgem3vVD1Ouj5tV2mTolxoX5x0ldMeX-M1MV2XU0

[5]  A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and ‘At-Risk’ Individuals - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC6770181/

[8] Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial

https://www.mdpi.com/2072-6643/16/9/1293

[9] [10] [12] New data drives home cognitive benefits of Noogandha

https://www.nutraingredients.com/Article/2024/06/11/New-data-drives-home-cognitive-benefits-of-Noogandha/

[11]  An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC6750292/

[13] [15]  Fusion Health Stress & Anxiety – Great Earth

https://greatearth.com/products/fusion-health-stress-anxiety

[14]  Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects - PMC

https://pmc.ncbi.nlm.nih.gov/articles/PMC3750820/