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SUPERFEAST Ashwagandha

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Ashwagandha

Ashwagandha's what people reach for when stress won't switch off.

In pooled trials it lowered blood cortisol and perceived stress scores over about eight weeks. Quality-of-life scores didn't shift in the same analysis, and the trials were often rated poor quality. Worth knowing both halves.

Christina Hanley, BHSc (Nutritional Medicine), Health Content Lead, Mr Vitamins

Christina HanleyBHSc (Nutritional Medicine), Health Content Lead
Checked this page October 2026

See what we checked

Is Ashwagandha right for you?

Ashwagandha suits a lot of people and it genuinely isn't for everyone. So here is the same quick triage our naturopaths run at the counter every day, in the order they run it.

A good fit if

  • You are an adult looking for traditional adaptogen support through a stretch of everyday stress
  • You want a standardised extract with the withanolide content printed on the label, so you know what you are taking
  • Your health history is straightforward. No liver, thyroid or autoimmune concerns, and no prescription medicines
  • You would rather stir a traditional whole-root powder into food or a drink than swallow a capsule
  • You are happy to give it a fair trial and review how you are going with a practitioner, rather than expecting an overnight change

Check with us first if

  • Thyroid condition, or taking thyroid hormone such as levothyroxine. Ashwagandha may alter thyroid hormone levels, and case reports describe thyrotoxicosis resolving after it was stopped.
  • Taking immunosuppressant medicines. A recognised potential interaction that should not be combined without medical advice.
  • Taking sedatives, anticonvulsants or anything else that causes drowsiness. Drowsiness is a recognised effect of ashwagandha and may be additive.
  • Taking diabetes or blood pressure medicines. Possible additive effects, so monitoring is advised.
  • Taking any prescription medicine at all. A quick check with your doctor, pharmacist or our naturopaths first is the sensible step.
  • Buying from an overseas website. Those products are not regulated by the TGA for quality and safety, and some reported liver injury cases involved internationally purchased products.

How the forms compare

  • Standardised root extract (generic). Best known for: The default on Australian listed medicine labels. Absorption: Concentrated, with withanolide content declared on the label, so the active dose is measurable. Typical use: Capsules or tablets, often split into two doses.
  • KSM-66 (branded root extract). Best known for: A root-only, water-based extract; used in 16 of 23 trials in one systematic review. Absorption: Aqueous root extract, standardised on total withanolides. Typical use: Capsules and sports powders, most often 600 mg per day. The most frequently studied dose.
  • Sensoril (branded root-and-leaf extract). Best known for: A root-and-leaf extract standardised to withanolide glycosides rather than total withanolides. Absorption: Leaf has a different phytochemical profile from root, so doses are not interchangeable with root-only extracts. Typical use: Dosed at the lower end of the range; uncommon on Australian labels.
  • Whole root powder. Best known for: Traditional Ayurvedic preparation, closest to historical use, stirred into milk, water or food. Absorption: Not concentrated. Far larger amounts are needed to match an extract's withanolide dose. Typical use: 1–2 teaspoons daily, measured by volume rather than by withanolide content.
  • Whole-herb or leaf-containing preparations. Best known for: Cheaper raw material; leaf and aerial parts rather than the root used in trials. Absorption: Leaf contains substantially higher withaferin A and withanone than root. Typical use: Uncommon on Australian labels; leaf material is one proposed contributing factor in reported liver injury cases.

Common questions

Is ashwagandha safe?

Most people tolerate standardised root extract well, and side effects reported in trials are usually mild. Nausea, loose stools, headache or drowsiness. Liver injury is rare but real, and the TGA has issued safety advisories about it. Avoid ashwagandha if you have any history of liver problems, and stop if jaundice appears.

What is the difference between KSM-66 and Sensoril ashwagandha?

Both are standardised extracts from different plant material. KSM-66 is a root-only, water-based extract standardised to at least five per cent withanolides, and it was used in most published trials. Sensoril is made from root and leaf and standardised to withanolide glycosides, so the two are not interchangeable milligram for milligram.

How much ashwagandha is typically taken?

Australian labels usually supply 150 to 600 milligrams of standardised root extract daily, and clinical trials most often used 300 to 600 milligrams for six to twelve weeks. Whole root powders are measured in teaspoons instead. Your needs depend on your age, diet and health circumstances. Talk to one of our naturopaths.

Who should not take ashwagandha?

Avoid it in pregnancy and breastfeeding, Australian withania medicines generally carry a pregnancy warning, and if you have liver problems. NIH guidance also advises against use with autoimmune conditions, hormone-sensitive prostate cancer or before surgery. Check first if you have a thyroid condition or take prescription medicines.

How much, and when

Reference values. None. Ashwagandha is a herb, not an essential nutrient, so there is no NHMRC Nutrient Reference Value, RDI or EAR for it.

Typical supplemental range. Australian labels typically supply 150–600 mg of standardised root extract per day. Combination tablets commonly provide 150 mg of extract equivalent to about 1.5 g of dry root, so the extract milligrams and the dry-root equivalent on a label are two different numbers.

Upper level. No NHMRC Upper Level of Intake exists. The 12 g dry root equivalent figure that appears in the TGA Determination is a labelling threshold inside a warning exemption, not a safety ceiling.

Worth knowing. Ashwagandha is not obtained from the everyday food supply in Australia, so there is no dietary intake figure to compare against. Duration matters as much as dose: long-term safety beyond about three months has not been established. Your needs depend on your age, diet and health circumstances. Talk to one of our naturopaths.

Before you start

This list is the part of the page we will not shorten. If any of it applies to you, talk to one of our naturopaths or your doctor before starting.

  • Pregnancy. Avoid without professional advice; NCCIH advises avoiding ashwagandha in pregnancy.
  • Breastfeeding. Avoid; safety has not been established (NCCIH).
  • Existing or previous liver problems. Avoid as a precaution.
  • Jaundice, dark urine, nausea, vomiting, unusual tiredness, abdominal pain or loss of appetite. Stop and seek medical advice promptly.
  • Sudden nausea, vomiting or diarrhoea after only one or two doses. Stop and seek advice; reported to the TGA.
  • Thyroid conditions, or thyroid hormone such as levothyroxine. May alter thyroid hormone levels; thyrotoxicosis case reports.
  • Autoimmune conditions. NCCIH advises against use.
  • Immunosuppressant medicines. Recognised potential interaction.
  • Sedatives, anticonvulsants and other drowsiness-causing medicines. Additive drowsiness.
  • Diabetes and blood pressure medicines. Possible additive effects; monitoring advised.
  • Planned surgery. NCCIH advises against use beforehand.
  • Hormone-sensitive prostate cancer. NCCIH advises avoiding.
  • Children and adolescents. Australian labels commonly state not suitable under 15.
  • Products bought from overseas websites. Not TGA-regulated for quality and safety; some reported liver injury cases involved internationally purchased products.
  • If you take prescription medicines, check with your doctor, pharmacist or our naturopaths before starting.

The evidence, and its limits

  • A meta-analysis of 15 trials in 873 adults found ashwagandha reduced blood cortisol and perceived stress scores at around eight weeks. (PubMed 40746175)
  • Withanolides are the marker compounds; Australian labels commonly standardise root extract to 5% withanolides. (PubMed 42198398)
  • Clinical trials most often use 300–600 mg daily of standardised root extract for six to twelve weeks. (PubMed 42198398)
  • Meta-analysis of 15 trials (873 adults) found reduced blood cortisol and perceived stress scores at eight weeks. (PubMed 40746175)
  • Quality-of-life scores did not improve in the same meta-analysis, and trial quality was frequently rated low. (PubMed 40746175)
  • Liver injury is rare but documented; roughly 23 published cases worldwide were identified by 2024. (National Institute of Diabetes and Digestive and Kidney Dise)

How it works

Ashwagandha is described as an adaptogen. A herb traditionally used to help the body cope with stress rather than acting on one organ. Its withanolides appear to act on the hypothalamic-pituitary-adrenal axis, the feedback loop that governs cortisol release, and on GABA-related signalling in the nervous system. Think of it less like a switch and more like turning down the gain on an over-sensitive alarm system. Mechanistic work is largely preclinical, so exactly how these effects translate in people is still being mapped.

The Australian rules

Withania somnifera is a permissible ingredient for Australian listed medicines, appearing as item 5218 in the Therapeutic Goods (Permissible Ingredients) Determination (No. 2) 2026, which commenced 11 June 2026. Its use carries a specific requirement: a pregnancy warning statement on the label, unless the product meets all four exemption conditions quoted below. Separately, the TGA has issued safety advisories about ashwagandha. In February 2024 covering sudden gastrointestinal reactions and liver-related reports, and a medicines safety update on 7 July 2026 describing a 'very rare risk of liver injury'. Being a permitted ingredient means the ingredient may lawfully be used in a listed medicine; it is not a government endorsement of the product or of any claim.

Read the instrument: Schedule 1, item 5218.

Not sure this is the right form for you? Ask one of our naturopaths. It is free and takes 10 minutes.

Always read the label and follow the directions for use. General information only, and not a substitute for advice from your doctor or one of our naturopaths.

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