CoQ10 150mg Plus Fish Oil

CoQ10 is one of the most-researched supplements on our shelves and one of the most misunderstood, so here is the triage our naturopaths run at the counter. What it suits, what needs a conversation first, and what rules it out.

A good fit if

• You are an adult with a straightforward health history and you are not taking prescription medicines
• You want the form question answered on the evidence rather than on price or packaging
• You are happy to take it with a meal that contains fat, which materially changes how much you absorb
• You would rather split a larger amount across the day than swallow it all at once
• You are comfortable reading the label, including the warfarin warning statement that every internal-use product carries

Check with us first if

• Taking warfarin. The Australian label warning directs you not to take CoQ10 while on warfarin therapy without medical advice. CoQ10 is structurally similar to vitamin K, has been reported to reduce warfarin's anticoagulant effect in a few cases, and has separately been reported to increase bleeding risk with it. If the two are used together, INR should be monitored frequently, especially in the first two weeks.
• Taking a statin. Do not stop or change a prescribed statin to take a supplement. Whether CoQ10 helps with statin-related muscle symptoms is genuinely unsettled, so this is a conversation to have with the doctor who prescribed it.
• Undergoing chemotherapy or radiotherapy. Antioxidants may reduce the effectiveness of these treatments, and in an animal model ubiquinone appeared to reduce the effect of radiation therapy. Decide this with your oncology team, not at the shelf.
• Taking theophylline. CoQ10 delays theophylline clearance, and the reported consequences are serious.
• Taking blood pressure medicines, insulin or other diabetes medicines. Additive effects are described, so monitoring is sensible.
• Pregnant or planning a pregnancy. Human safety data are limited and confined to specific research settings, so this is a practitioner decision rather than a self-serve one.
• Buying for a child or teenager. No Australian paediatric limit is set for this ingredient and retail products are formulated for adults, which makes the dose a practitioner question.
• Taking more than about 200 mg a day. This is where gastrointestinal complaints such as nausea, heartburn and loose stools are most often reported.
• Buying from an overseas website. Those products are not TGA-regulated for quality and safety, and the 300 mg Australian ceiling does not apply to them.

• Ubiquinone (ubidecarenone). Best known for: The original and most-studied form. Almost all of the older clinical literature used it. Absorption: Must be reduced to ubiquinol on the way through; a 2026 crossover measured about half the plasma exposure of a ubiquinol product at 240 mg. Typical use: The default on Australian labels, usually 50–300 mg once daily with a meal containing fat.
• Ubiquinol (ubiquinol-10). Best known for: Arriving pre-reduced, so it does not have to be converted before it can act as an antioxidant. Absorption: Roughly 2.0–2.2 times the plasma AUC and peak of a ubiquinone comparator in one 12-person crossover; a 2020 review disputes that the redox form is the reason. Typical use: Often chosen for adults over about 40 or on statins; costs more per milligram and is less stable in the capsule.
• Oil-suspension softgel. Best known for: Dissolving the CoQ10 in a carrier oil such as rice bran, soy or palm oil before it is swallowed. Absorption: The carrier lipid and the degree of crystal dispersion are described as primary determinants of uptake. Arguably more so than which redox form is used. Typical use: The most common presentation for both forms; the oil base is why softgels dominate the category.
• Dry powder tablet or hard capsule. Best known for: Lower cost, vegan-friendly options and multi-ingredient formulas where an oil fill is impractical. Absorption: Depends heavily on whether the raw CoQ10 crystals have been thermally dispersed; undispersed crystalline material absorbs poorly. Typical use: Combination products, B-complex, multivitamins, magnesium blends, and vegan single-ingredient tablets.
• Solubilised, micellar or liposomal liquids. Best known for: Engineering around the fat-solubility problem rather than relying on the meal to supply the fat. Absorption: Marketed on enhanced uptake; head-to-head human data against a well-dispersed oil softgel is thin, so treat comparative figures cautiously. Typical use: Premium liquids and sprays, and a practical option for people who cannot swallow softgels.
• Topical CoQ10 in skincare. Best known for: Cosmetic use in creams, serums and sunscreens. A different product category entirely. Absorption: Not relevant to blood levels; regulated as an excipient at up to 0.05% and not permitted in medicines intended for the eye. Typical use: Applied to skin; contributes nothing to your internal CoQ10 status.

Reference values. None. The body synthesises CoQ10, so it is not classed as an essential nutrient and the NHMRC Nutrient Reference Values set no RDI, EAR or Adequate Intake for it. There is no amount you are required to obtain from food or supplements.

Typical supplemental range. Australian labels most often supply 50–300 mg a day, with 150 mg the most common single-capsule strength and 300 mg the high-strength tier. Internationally, standard over-the-counter products sit lower, at 30–100 mg a day. Research using CoQ10 for inherited coenzyme Q10 deficiency runs far higher, 1,200 to 3,000 mg a day in adults, but that is a supervised clinical setting, not a retail one.

Upper level. No NHMRC Upper Level of Intake exists for CoQ10. Australia imposes its own regulatory ceiling instead, and because it is a legal limit on what may be sold rather than a nutritional one, it is quoted verbatim in the Australian status section below.

Worth knowing. Two practical points change absorption more than the brand does. First, CoQ10 is fat-soluble and is best absorbed with fat in a meal, so a capsule taken with breakfast toast is not the same as one taken with an oily lunch. Second, absorption in a single dose appears to have a finite capacity, so amounts above 100 mg are generally split into two or three doses across the day; one comparison found 2 x 100 mg raised serum levels more than a single 200 mg dose. Plasma levels take one to two weeks to reach a steady state, and stop rising altogether at very high intakes. Your needs depend on your age, diet and health circumstances. Talk to one of our naturopaths.

Food first, where the diet allows it.

• Beef, fried: about 2.6 mg per 85 g (3 oz) serve: meat, poultry and fish are the richest dietary sources
• Herring, marinated: about 2.3 mg per 85 g serve; oily fish is the strongest non-meat source
• Chicken, fried: about 1.4 mg per 85 g serve
• Soybean and canola oil: about 1.3 mg and 1.0 mg per tablespoon respectively: the main plant-food contributors
• Peanuts, roasted: about 0.8 mg per 28 g (1 oz) handful
• Broccoli, boiled: about 0.5 mg per half cup; fruit, vegetables, eggs and dairy contribute only modest amounts

This list is the part of the page we will not shorten. If any of it applies to you, talk to one of our naturopaths or your doctor before starting.

• Warfarin. Mandatory Australian label warning: do not take while on warfarin therapy without medical advice. Reduced anticoagulant effect and increased bleeding risk both reported; monitor INR frequently, especially in the first two weeks.
• Statin therapy. Never stop or alter a prescribed statin to take CoQ10; evidence on statin-related muscle symptoms is conflicting.
• Chemotherapy and radiotherapy. Antioxidants may reduce treatment effectiveness; ubiquinone reduced radiation effect in an animal model. Oncology advice required.
• Theophylline. CoQ10 delays theophylline clearance; persistent vomiting, cardiac arrhythmia and intractable seizures reported.
• Antihypertensive medicines. Possible additive blood-pressure effect; monitoring advised.
• Insulin and diabetes medicines. Possible additive effect; monitoring advised.
• Pregnancy. Limited human safety data; practitioner advice required.
• Breastfeeding. Avoid; safety not established.
• Children and adolescents. No Australian paediatric limit set for this ingredient; retail products are formulated for adults.
• Doses of 200 mg a day or more. Nausea, diarrhoea, appetite suppression, heartburn and abdominal discomfort most often reported at this level.
• Hypersensitivity to CoQ10 or to any product ingredient, including carrier oils and softgel shells.
• Products bought from overseas websites. Not TGA-regulated for quality and safety, and not bound by the Australian 300 mg limit.
• Not to be included in medicines intended for use in the eye (Permissible Ingredients Determination).
• If you take prescription medicines, check with your doctor, pharmacist or our naturopaths before starting.