Ultra Nature

Propolis & Manuka Honey Oral Spray

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Ultra Nature Propolis and Manuka Honey Oral Spray is an oral liquid in a handy 30 mL pump spray, combining honey and propolis resin with ivy leaf and chamomile flower extracts in a peppermint flavoured base. Adults use it to relieve the symptoms of mild mouth ulcers and of mild throat infection, and to support oral health. The compact pump spray is easy to keep close by.

Product Strengths

Honey 18.6 mg and propolis resin 1.3 mg, equivalent to propolis 6.5 mg, in every mL.
Ivy leaf and chamomile flower extracts, each equivalent to 20 mg of dry herb per mL.
Decrease, reduce or relieve symptoms of mild mouth ulcers.
Decrease, reduce or relieve symptoms of mild throat infection.
Maintain and support oral health, and decrease or reduce halitosis.
Antioxidant that helps reduce free radical damage to body cells.
Peppermint flavoured, in a 30 mL spray.

Suitable For / Not Suitable For

Suitable for: Adults using an oral spray for the mouth and throat.

Not suitable for: Anyone with an allergy to the listed ingredients; infants under twelve months of age; anyone allergic to bee products, because the spray contains propolis and honey; anyone sensitive to the daisy family, because chamomile is an Asteraceae; and anyone avoiding sorbitol, which the base contains.

Ingredients

Each mL contains	Amount
Honey	18.6 mg
Hedera helix (ivy) leaf extract dry concentrate	2 mg (equiv. dry 20 mg)
Matricaria chamomilla (chamomile) flower extract dry concentrate	2 mg (equiv. dry 20 mg)
Propolis resin	1.3 mg (equiv. propolis 6.5 mg)

Excipients: glycerol, maltodextrin, peppermint oil, purified water, sorbitol solution (70 per cent) non-crystallising.

Always review label for full list of ingredients.

Suggested Use

Adults: take as directed on the label. Do not exceed the recommended daily dose.

Warnings

WARNING: Propolis may cause allergic reactions. If irritation or swelling of the mouth or throat occurs, discontinue use.
Not suitable for infants under the age of twelve months.
If symptoms persist, talk to your health professional.
Keep out of reach of children.

TGA Listing

Listed on the Australian Register of Therapeutic Goods as AUST L 450386. Listed medicines carry an AUST L number and are assessed by the TGA for quality and safety, not for efficacy.

Storage

Store in a cool, dry place away from direct sunlight, with the cap closed between uses. Keep out of reach of children.

Disclaimer

Always read the label and follow the directions for use. If symptoms persist, talk to your health professional.

Ingredients

Propolis; Manuka Honey (UMF 20+); Peppermint Oil;
Chamomile; Ivy Leaf Extract; Sorbitol.

Always use as directed: Don’t use if allergic or hypersensitive to Propolis or other ingredients in the formulation. If irritation or swelling of the mouth or throat occurs, discontinue use. Not recommended for children under the age of 2.

Suggested dose

Adults and children over 13 years old: 3 sprays up to 3 times per day as required. Children from 2 – 13 years old: 2 sprays up to 3 times per day as required. Spray directly into mouth. Shake well before use.

Store below 30°C and away from direct heat and sunlight. Keep out of reach of children. Do not use if tamper evident seals are broken or are missing.

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Propolis

What is propolis used for?

Propolis is the resin bees gather from trees to seal and protect their hive, and it's used in mouthwashes, sprays and lozenges. These put it right where you want it, on your mouth, gums and throat.

Christina Hanley, BHSc (Nutritional Medicine), Digital Experience & Content Manager, Mr Vitamins

Christina HanleyBHSc (Nutritional Medicine), Digital Experience & Content Manager
Checked this page September 2026

See what we checked

Is Propolis right for you?

With propolis, the format makes all the difference. These are the questions our naturopaths ask in store before picking one off the shelf.

A good fit if

You want it for your mouth, gums or throat, which is where most of the evidence is
You'd rather use a mouthwash or lozenge than swallow a capsule
You want a standardised extract and understand why that matters with propolis
You've used it before with no reaction

Check with us first if

You react to bees, bee products, pollen or tree resins, because propolis is a known allergen.
You're having cancer treatment. Mouth care is worth talking through with your treating team.
You're thinking of using it for blood sugar alongside diabetes medicine.
You're buying for a child. There's no safety data for children.
You've had contact dermatitis from a skin product before.

How the forms compare

Mouthwash. Best known for: Mouth sores from cancer treatment (oral mucositis). This is the clearest result in the evidence. Absorption: Works by direct contact with the lining of the mouth rather than being absorbed into the body. Typical use: The format most of the mouth trials actually used.
Toothpaste, dentifrice or lozenge. Best known for: Plaque and bacteria levels in the mouth. Absorption: Delivered every day as part of your oral care, with repeated contact. Typical use: Plaque scores improved compared with no-treatment controls across 45 studies.
Standardised Brazilian green propolis extract. Best known for: A defined, well-characterised extract rather than a raw material that varies. Absorption: Studied at 900 mg a day for 10 days in hospital patients. Typical use: The way around the problem of variable make-up, if that matters to you.
Tincture. Best known for: The traditional liquid, extracted in alcohol. Absorption: None of the trials we reviewed used a tincture. Typical use: Familiar, but not the format that was studied.
Capsules. Best known for: Propolis you swallow, studied for blood sugar and markers of inflammation. Absorption: Absorbed into the body rather than working locally. Typical use: This is where the blood sugar evidence sits, rather than the mouth evidence.

Common questions

What's propolis actually for?

Most of the evidence is about the mouth. Propolis mouthwash reduced severe mouth ulcers (oral mucositis) across five randomised trials in people having cancer treatment, and propolis products reduced dental plaque across 45 studies. There's a smaller amount of research on swallowed propolis and blood sugar markers. If you want it for your mouth, pick a format that stays in your mouth.

Why does the label warn about allergic reactions?

Because propolis is a known allergen. Australian law requires every product you swallow or take by mouth to carry the warning: if irritation or swelling of the mouth or throat occurs, stop using it. Skin products carry a separate skin irritation warning and tell you to test before use. If you react to bees, pollen or tree resins, propolis isn't for you.

Why does propolis vary so much between brands?

Because bees make it from whatever trees grow near the hive, so what's in it changes from place to place. That's why Brazilian green propolis and a European propolis aren't chemically the same. If that matters to you, look for a standardised extract that states what it contains, rather than a generic raw propolis.

How much, and when

Reference values. There's no Nutrient Reference Value for propolis, because it's a hive product, not a nutrient.

Typical supplemental range. Trial doses depend on the format. Trials for mouth ulcers during cancer treatment (oral mucositis) used a propolis mouthwash rather than a set milligram dose. A standardised Brazilian green propolis extract was studied at 900 mg a day for 10 days in people in hospital. The blood sugar review pooled 21 randomised trials using different doses, rather than settling on one.

Upper level. None is set, and Australia's permitted ingredients list (Schedule 1) has no daily dose cap for any form of propolis. The one firm number is a purity limit rather than a dose: lead must be no more than 0.001% of the medicine.

Worth knowing. Match the format to the job: mouthwashes, sprays and lozenges for your mouth and throat, and capsules if you're following the research on swallowed propolis. What you need depends on your age, diet and health, so talk to one of our naturopaths.

Before you start

If any of these sound like you, talk to one of our naturopaths or your doctor before you start.

You are allergic to bees, pollen or resins. Propolis is a known allergen, which is why both Australian warnings exist. We found no source that puts a number on how often reactions happen.
Taking it by mouth. The required warning (PROP2) reads: "Warning: Propolis may cause allergic reactions. If irritation or swelling of the mouth or throat occurs, discontinue use."
Using it on the skin. The required warning (PROP1) reads: "WARNING: Propolis may cause skin irritation. Test before use".
Lead content. Schedule 1 caps lead at no more than 0.001% of the medicine, because lead is a listed component of propolis.
Children. The propolis items have no age limit, but we hold no safety data on propolis in children either.
You have diabetes and take medicine for it. Propolis lowered fasting glucose and HbA1c in pooled trials, so talk to us before adding it.
If you take prescription medicines, check with your doctor, pharmacist or our naturopaths before you start.

The evidence, and its limits

Propolis is a natural resin made by bees. The clinical literature describes it as helping skin heal over and stimulating skin regeneration. (DOI record)
Across 5 trials in 209 people with cancer, propolis mouthwash lowered the rate of severe mouth sores, or oral mucositis (OR 0.35). (PubMed 30022350)
Across 45 studies, propolis products reduced plaque scores compared with no-treatment controls (SMD -1.11). (PubMed record)
Across 21 trials, propolis taken by mouth lowered fasting glucose by 9.75 mg/dL and HbA1c by 0.46%. (PubMed record)
Across 20 trials in 1,139 adults, C-reactive protein (an inflammation marker) did not fall overall, only when propolis was taken for 10 weeks or more. (PubMed record)
Its make-up varies enormously with the trees near the hive, so two jars from different countries differ chemically. (DOI record)

How it works

Propolis is the hive's antiseptic, and most of the research has looked at it working where it touches, rather than throughout your body. When it's in contact with your mouth, throat or gums, the resins do their work right where they land. That's why mouthwashes and lozenges make up most of the trial evidence, and why the clearest result is for mouth ulcers during cancer treatment. There's also a smaller amount of research on swallowed propolis and blood sugar markers. One thing applies across all of it: propolis changes with where it comes from, so two jars from different countries aren't the same material.

The Australian rules

Propolis is item 4160 on Australia's permitted ingredients list (Schedule 1, Determination No. 2 of 2026), and propolis balsam (4161), dry extract (4162) and liquid extract (4163) have the same conditions. Two things apply to all of them. First, a limit on make-up: lead is listed as a required component of propolis and must be no more than 0.001% of the medicine, an unusual rule that reflects what the raw material actually contains. Second, two required warnings, depending on how it is used: products for the skin carry a skin irritation warning, and everything else carries an allergic reaction warning. There is no daily dose cap on any form of propolis and no age limit. Compare that with royal jelly (item 4373), a related hive product that must carry "Not suitable for children". Being allowed is not the government endorsing any product or claim.

Read the instrument: Schedule 1, item 4160.

Not sure this is the right form for you? Ask one of our naturopaths. It is free and takes 10 minutes.

Always read the label and follow the directions for use. General information only, and not a substitute for advice from your doctor or one of our naturopaths.

Propolis & Manuka Honey Oral Spray

Shipping

Click & Collect

Consult

Terms and Conditions

Description

Product Strengths

Suitable For / Not Suitable For

Ingredients

Suggested Use

Warnings

TGA Listing

Storage

Disclaimer

ingredients

suggested dose

Product Strengths

Suitable For / Not Suitable For

Ingredients

Suggested Use

Warnings

TGA Listing

Storage

Disclaimer

Ingredients

Suggested dose

What is propolis used for?

Is Propolis right for you?

What's propolis actually for?

Why does the label warn about allergic reactions?

Why does propolis vary so much between brands?

How much, and when

Before you start

The evidence, and its limits

Reviews and Q&A

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