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Niacin 100mg Extended Release

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Niacin (Nicotinic Acid)

What does niacin do?

Niacin helps your body release energy from food and keeps your nerves working normally. Nicotinic acid is the original, classic form of vitamin B3, the one known for its warm flush at higher doses.

Christina Hanley, BHSc (Nutritional Medicine), Digital Experience & Content Manager, Mr Vitamins

Christina HanleyBHSc (Nutritional Medicine), Digital Experience & Content Manager
Checked this page October 2026

See what we checked

Is this the right vitamin b3 for you?

Nicotinic acid is the form of B3 with a real history in cholesterol research. These are the questions our naturopaths ask in store before you choose it over nicotinamide.

A good fit if

  • Your diet is light on chicken, fish, peanuts and mushrooms, which is where most niacin in food comes from
  • You're topping up to around the recommended intake, usually through a B complex or multivitamin
  • A practitioner has specifically recommended nicotinic acid and you're following their dose
  • You know a listed medicine can contain no more than 100 mg of it per dose unit

Check with us first if

  • You take a statin. Adding gram doses of niacin didn't reduce heart events in either large trial, and the HPS2-THRIVE trial found significantly more serious side effects.
  • High cholesterol is the reason you're shopping. That's one for your doctor, and the modern evidence doesn't support adding niacin to statin treatment.
  • You're pregnant or breastfeeding. Your recommended intake is higher, but a high-strength product is a different conversation.
  • You take prescription medicine. Check with your doctor, pharmacist or our naturopaths before you start.

How the forms compare

  • Nicotinic acid (niacin). Best known for: The flushing form, and the one with a history in blood fat research. Absorption: Well absorbed by mouth. The flush and the effects on blood fats at gram doses belong to this form, not the other one. Typical use: Capped at 100 mg per dosage unit (such as a tablet) in a listed medicine. Gram doses added to statin treatment didn't reduce cardiovascular events, and HPS2-THRIVE, which tested niacin with laropiprant, recorded significantly more serious side effects.
  • Nicotinamide (niacinamide). Best known for: The form that doesn't cause flushing at any studied dose, and doesn't change blood fats. Absorption: Well absorbed by mouth, and it doesn't use the pathway that causes the flush. Typical use: The active in most higher-strength Australian B3 tablets, because Schedule 1 sets no cap for it.
  • Inositol hexanicotinate ("no-flush niacin"). Best known for: Six nicotinic acid molecules bound to inositol, sold as niacin without the flush. Absorption: Not well understood. An analysis of products on sale found several released almost no free nicotinic acid. Typical use: It isn't in Schedule 1 under its own name, so it can't be the active in a listed medicine. Nicotinamide is the allowed flush-free form.

Common questions

Will niacin lower my cholesterol?

The niacin doses tested for blood fats were 1,500 to 3,000 mg a day under medical supervision, and Australian rules cap a listed medicine at 100 mg per dose unit, so a product from the shelf can't match that dose. When the AIM-HIGH trial added a gram dose to statin treatment in 3,414 people, heart and blood vessel events were 16.4%, against 16.2% on placebo, and the trial was stopped early because it wasn't helping. HPS2-THRIVE, an even larger trial, found no drop in these events and more serious side effects. If cholesterol is why you're shopping, talk to your doctor.

Why does niacin make me flush?

At higher doses, nicotinic acid triggers a flush in the skin: warmth, redness, itching or tingling, usually across your face and upper body. It's uncomfortable rather than dangerous, and it's the main reason people stop taking this form. Nicotinamide doesn't cause it at any dose studied, because it works through a different pathway. If a product makes you flush and you'd rather it didn't, change to a different form on the label.

Is no-flush niacin the same as this?

No. "No-flush niacin" is inositol hexanicotinate, six nicotinic acid molecules joined to one inositol molecule, and it's a separate substance. It isn't on Australia's permitted ingredients list under its own name, so it can't be the named active ingredient in an Australian listed medicine. An analysis of no-flush products found several released almost no free nicotinic acid, which undermines the reason they're sold. If you'd like to avoid the flush, nicotinamide is the better-understood choice.

How much, and when

Reference values. Australia's recommended intake is 16 mg a day for adult men and 14 mg for women, as niacin equivalents, and nicotinic acid counts towards this the same way nicotinamide does. In pregnancy it's 18 mg, and while breastfeeding 17 mg.

Typical supplemental range. Australia's permitted ingredients list (Schedule 1) allows no more than 100 mg of nicotinic acid per dose unit in a listed medicine, so products on the shelf are far below the gram doses used in cholesterol research. Those trials used 1,500 to 3,000 mg a day under medical supervision, well beyond anything sold as an everyday supplement.

Upper level. The adult upper limit for nicotinic acid is 35 mg a day from supplements and fortified foods. It's 30 mg at 14 to 18, 20 mg at 9 to 13, 15 mg at 4 to 8, and 10 mg at 1 to 3. In pregnancy the limit is 30 to 35 mg depending on age, and 35 mg while breastfeeding.

Worth knowing. The 100 mg per dose cap and the 35 mg adult upper limit are both well under the gram doses tested for cholesterol, which is one reason a supplement from the shelf can't match that use. What you need depends on your age, diet and health, so talk to one of our naturopaths.

Food sources

Food first, where the diet allows it.

  • Peanuts, roasted, 100 g: 18 mg niacin
  • Chicken breast, 100 g: 11 mg niacin
  • Sunflower seeds, 100 g: 10.75 mg niacin
  • Mushrooms, fresh, 100 g: 3.55 mg niacin
  • Potato, peeled, 100 g: 1.73 mg niacin

Before you start

If any of these sound like you, talk to one of our naturopaths or your doctor before you start.

  • If you take a statin. Adding gram-dose niacin gave no benefit in AIM-HIGH or HPS2-THRIVE, and HPS2-THRIVE recorded significantly more serious side effects.
  • Using it for cholesterol. Current trial evidence doesn't support adding niacin to statin treatment; talk to your doctor.
  • Children. The upper level is 10 mg a day at ages 1 to 3, far below the strength of an adult product.
  • Pregnancy and breastfeeding. The recommended intake is higher (18 mg and 17 mg), but a high-strength product needs a separate conversation with your doctor.
  • If you take prescription medicine. Check with a doctor or pharmacist before taking a high-dose niacin product.
  • If you take prescription medicines, check with your doctor, pharmacist or one of our naturopaths before you start.

The evidence, and its limits

  • The niacin in nicotinic acid helps your body release energy from food, and keeps your nervous system healthy. (healthdirect Australia)
  • Adults need 16 mg a day (men) or 14 mg (women) of niacin equivalents, whichever form it comes from. (NHMRC nutrient reference values)
  • Schedule 1 caps nicotinic acid at 100 mg per dosage unit in an Australian listed medicine. (Schedule 1, items 3487, 3491)
  • AIM-HIGH found no extra cardiovascular benefit when niacin was added to statin treatment (16.4% versus 16.2%). (PubMed 22085343)
  • HPS2-THRIVE recorded significantly more serious side effects when niacin was added to statin treatment. (PubMed 25014686)
  • The adult upper level is 35 mg a day from supplements, far below the gram doses in the blood fat trials. (NHMRC nutrient reference values)

How it works

Your body turns nicotinic acid into NAD and NADP, the same coenzymes it makes from nicotinamide, and around 400 enzyme reactions rely on them, including the ones that turn food into energy and repair DNA. What sets nicotinic acid apart is what happens at much higher doses. At gram doses it triggers a flush in the skin (warmth, redness, itching or tingling, usually across your face and upper body), and it also raises HDL cholesterol and lowers triglycerides and LDL. That effect on blood fats is real, but two large modern trials found it didn't lead to fewer heart attacks or strokes in people already taking a statin, and one of them found more serious side effects.

The Australian rules

NICOTINIC ACID is item 3491 on Australia's permitted ingredients list (Schedule 1, Determination No. 2 of 2026). It can be the declared active in an Australian listed medicine, with one condition: 'The medicine must contain no more than 100 mg of nicotinic acid per dosage unit.' That's a real contrast with NICOTINAMIDE, item 3487, which has no such cap. 'Vitamin B3' isn't a Schedule 1 name in itself, so a label has to declare one of the two forms. Inositol hexanicotinate, sold as no-flush niacin, isn't in Schedule 1 under its own name. Being allowed isn't the government endorsing a product or any claim made for it.

Read the instrument: Schedule 1, items 3487, 3491.

Not sure this is the right form for you? Ask one of our naturopaths. It is free and takes 10 minutes.

Niacin (Nicotinic Acid) is one form of Vitamin B3. Always read the label and follow the directions for use. General information only, and not a substitute for advice from your doctor or one of our naturopaths.

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