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A spotlight on Palmitoylethanolamide (PEA) for pain

Chronic pain is a burden of considerable magnitude. Approximately 3.37 million Australians are currently living with ongoing pain which incurs substantial financial strain.

A spotlight on Palmitoylethanolamide (PEA) for pain
  • Health advice
  • Aug 20, 2025

Chronic pain is a burden of considerable magnitude. Approximately 3.37 million Australians are currently living with ongoing pain which incurs substantial financial strain, with costs estimated to be as high as $144.1 billion annually for the country.

The problem with pain

Pain is a vital, complex protective mechanism, telling your body something is wrong and needs attention, and exists to protect the body from danger and harm. There are two main types of pain: acute pain, the normal response to an injury that is usually sudden and short-lived, and chronic pain that continues beyond the time expected for healing. When pain becomes chronic, it can severely impact day-to-day functions, wellbeing and quality of life. Common causes of chronic pain include mild arthritis, musculoskeletal ailments, nerve pain and surgery.

A place for PEA

Palmitoylethanolamide (PEA) is a unique fatty acid amide first isolated in 1957, and although it was discovered over 70 years ago, it has recently been a hot topic for its ability to relieve pain in a variety of pain states. PEA is produced naturally in the body in response to injury, pain, inflammation and stress. It can be found in all body tissues, however, it is most abundantly found in the central nervous system. Recently, building research is shining a light on this distinctive compound and its role in the body, particularly in relation to its benefit for pain relief. 

How does PEA work?

PEA works by acting on multiple mechanisms in the body that control inflammation and pain sensation. It acts directly and indirectly on several targets to a produce a positive therapeutic effect on the central nervous system and, unlike regular fats, amide-containing fatty acids like PEA are directly involved in nerve communication. Meaning, it acts like a neurotransmitter to modulate our perception of pain.

How can this help me?

PEA relieves:

  • Acute or chronic pain
  • Symptoms of mild arthritis and mild osteoarthritis
  • Mild joint aches and pain
  • Mild nerve pain or neuralgia

The body produces PEA in such small amounts, that often there is not enough to help combat the increased stress that occurs in our bodies every day. Small amounts are present in foods from foods such as soybean lecithin, egg yolk and peanuts, and PEA in supplemental form is known to be poorly absorbed in the gastrointestinal tract.

 

This is where Pain Relief PEA Forte – Herbs of Gold steps in! Pain Relief PEA Forte contains PEA as Levagen®+, a clinically studied form of PEA that uses LipiSperse® technology for increased bioavailability in the body.

References:

  1. Australian Institute of Health and Welfare. (2020). Chronic Pain in Australia.
  2. Pain Australia. (2020). Painful Facts.
  3. Steels, E., Venkatesh, R., Steels, E., Vitetta, G., & Vitetta, L. (2019). A double-blind randomised placebo-controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Inflammopharmacology, 27(3), 475-485.

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