- Health advice
- Mar 16, 2026
The best stress support supplements typically fall into two broad categories: activated B-vitamin formulas that replenish nutrients depleted during periods of high stress, and adaptogenic herbal blends - such as ashwagandha and holy basil - that help the body build resilience to physical and emotional pressure.
At Mr Vitamins, our team of qualified naturopaths and nutritionists has reviewed the leading practitioner-grade options available in Australia.
Based on their clinical experience, four supplements stand out for stress management support in 2026: Herbs of Gold Activated B Stress, Designs for Health TriGandha, Fusion Health Stress & Anxiety, and Eagle Tresos Activated B PluSe.
Each formula targets a different aspect of the stress response - from nervous system support and cortisol balance to mental clarity and burnout recovery. Read on for a full breakdown of ingredients, benefits, dosage, and who each supplement is best suited for.
Top 4 Supplements For Managing Stress
Below are four stress supplements recommended by practitioner Christina Hanley that may help support the body's natural stress response.
- Herbs of Gold Activated B Stress
- Designs for Health TriGandha
- Fusion Health Stress & Anxiety
- Eagle Tresos Activated B PluSe
4 Top Stress Relief Supplements - Quick Comparison
If you're looking for support during times of stress, these supplements offer a mix of activated B vitamins, adaptogenic herbs, and practitioner-grade nutrient formulas. The table below compares the main ingredients, benefits, dosage, pack size, and warnings for each option.
| Product | Type | Main Ingredients | Best For | Dosage | Size | Warnings |
|---|---|---|---|---|---|---|
| Herbs of Gold Activated B Stress | Combo | Holixer™ holy basil, activated B2, B6, B12, folate, vitamin C | Stress-related fatigue & low energy | 1 tablet daily with food | 60 tablets |
|
| Designs for Health TriGandha | Herbal | Sensoril®, NooGandha®, Shoden® - 650 mg ashwagandha total | Calm mind, anxiety & high stress load | 1 capsule daily | 60 capsules |
|
| Fusion Health Stress & Anxiety | Herbal | KSM-66® ashwagandha, OciBest® holy basil, polygala, magnolia bark, poria, citrus peel | Nervous tension, anxiety & sleep-related stress | 2 tablets twice daily with food | 60 or 120 tablets |
|
| Eagle Tresos Activated B PluSe | Vitamin | Activated B vitamins, vitamins A, C, D, E, magnesium, selenium, zinc, taurine, glutamine, bromelain | Burnout recovery & long-term stress resilience | 1 tablet daily with food | 60 or 150 tablets |
|
Looking for more options? Explore our full collection of stress support supplements and magnesium supplements.
Herbal vs Nutritional: Which Approach Suits You?
- Best for: anxiety, nervous tension, racing thoughts
- How they work: help the body adapt to stress via the HPA axis
- Key herbs: ashwagandha, holy basil, polygala, magnolia bark
- Onset: calming effects often felt within 1–2 weeks
- Consider: may interact with sedatives or thyroid medication
- Best for: stress-related fatigue, burnout, low energy
- How they work: replenish nutrients depleted during high stress
- Key nutrients: B vitamins, magnesium, zinc, selenium, vitamin C
- Onset: energy and resilience improvements over 2–4 weeks
- Consider: good foundation alongside herbal support
Which Stress Supplement Is Right for You?
4 Best Stress Supplements - Full Breakdown
1. Herbs of Gold Activated B Stress
Best for: stress-related fatigue & low energy
View Herbs of Gold Activated B Stress at Mr Vitamins
What it is: A one-a-day activated B-vitamin complex with added Holy Basil herbal extract, designed to relieve symptoms of stress and support energy levels.
Key Ingredients
Holy Basil (Ocimum tenuiflorum) - 250 mg of Holixer™
Holy basil is a natural adaptogenic herb that helps your body cope with stress, supporting balance when you're feeling run down or overwhelmed. Research on the Holixer™ extract found that people experienced lower stress levels and better sleep after 8 weeks - with stress ratings dropping by about 37% compared to 19% with placebo.
B-Complex Vitamins (B1, B2, B3, B5, B6, B9, B12, Biotin)
This formula contains high-strength, ready-to-use activated forms of all key B vitamins. B vitamins play an important role in energy production and nervous system health. During times of stress, your need for B vitamins increases as they help support the adrenal glands and the production of brain chemicals that regulate mood and focus.
Vitamin C (250 mg as ascorbic acid)
A powerful antioxidant used by the adrenal glands during stressful times. May help reduce feelings of fatigue and physical strain while protecting cells from oxidative damage.
How it helps
- B vitamins help convert food into energy and support the nervous system, reducing mental fatigue
- Holy Basil promotes relaxation and helps lower stress levels
- Helps you feel more energised, focused, and balanced
Dosage: 1 tablet daily with food, or as directed by a healthcare professional.
Size: Available in 30 or 60 tablet bottles.
Always read the label and follow directions for use. Contains vitamin B6 - stop taking and consult a healthcare practitioner if you experience tingling, burning, or numbness. Vitamin supplements should not replace a balanced diet. Seek professional advice during pregnancy or breastfeeding.
2. Designs for Health TriGandha
Best for: calm mind, anxiety & high stress load
View Designs for Health TriGandha at Mr Vitamins
What it is: A herbal stress support supplement made with three types of ashwagandha extract, designed to deliver the full benefits of this well-known adaptogen for stress, mood, and overall vitality.
Key Ingredients (per capsule)
Sensoril® - 250 mg
A patented extract from ashwagandha root and leaf known for its potent anti-stress and cortisol-lowering effects. By modulating the HPA axis (the body's stress response system), Sensoril helps reduce anxiety and fatigue and supports adrenal balance.
NooGandha® - 250 mg
A newer liposomal ashwagandha extract designed for cognitive benefits. Research has found it can improve short-term memory, focus, and reaction time in healthy adults, while also reducing markers of stress in people with high perceived stress.
Shoden® - 150 mg
A concentrated ashwagandha extract that helps lower stress levels, ease anxiety, support better sleep, and promote a balanced mood.
How it helps
- Helps reduce stress and support adrenal health
- Supports focus and mental clarity under pressure
- Promotes balanced mood and steady energy
A good choice for busy professionals or students with high stress who also want cognitive support. Contains no stimulants and can be taken alongside other supplements.
Dosage: 1 capsule daily with food, or as directed by a healthcare practitioner.
Size: 60 capsules per bottle (30 servings).
Practitioner-recommended product. Consult your practitioner for dose guidance. Avoid if allergic to ingredients. Consult a practitioner if pregnant, breastfeeding, or on medications - particularly sedatives or thyroid-related medication. Always read the label and follow directions for use.
3. Fusion Health Stress & Anxiety
Best for: nervous tension, anxiety & sleep-related stress
View Fusion Health Stress & Anxiety at Mr Vitamins
What it is: A herbal stress support formula combining ingredients from traditional Ayurvedic and Chinese medicine, designed to promote calmness while supporting focus and energy.
Key Ingredients (per tablet)
Fusion uses trademarked, clinically tested herb extracts where available, alongside traditional herbal preparations.
Ashwagandha (Withania somnifera) - 187.5 mg of KSM-66® extract (from 1.88 g root)
KSM-66® is a highly concentrated ashwagandha root extract known for its stress-reducing and mood-supporting benefits. Research suggests it helps reduce symptoms of stress and anxiety while supporting energy and mental balance.
Holy Basil (Ocimum tenuiflorum) - 300 mg of OciBest® extract (from 3 g whole herb)
Also known as Tulsi, holy basil is traditionally used to promote calmness and emotional wellbeing. The OciBest® extract has been shown to help reduce stress and support healthy cortisol levels.
Polygala (Polygala tenuifolia) - 75 mg extract (from 750 mg root)
Called Yuan Zhi in traditional Chinese medicine, polygala has long been used to settle the mind, ease mild anxiety, reduce irritability, and support better sleep.
Magnolia Bark (Magnolia officinalis) - 93.8 mg extract (from 750 mg bark)
Contains natural compounds that may help reduce stress, tension, and anxious feelings. Research suggests it can support mood and relaxation, calming the nervous system without causing daytime drowsiness.
Poria Mushroom (Wolfiporia cocos) - 100 mg extract (from 500 mg sclerotium)
A traditional Chinese herbal ingredient used to calm the mind, promote relaxation, and support better sleep alongside the other herbs in this formula.
Citrus Peel (Citrus reticulata) - 75 mg extract (from 750 mg dried peel)
Traditionally used in Chinese medicine to support healthy digestion, particularly when stress affects the stomach. May help reduce indigestion, bloating, or nervous butterflies.
How it helps
- Ashwagandha and holy basil help your body cope with stress and support mood balance
- Traditional Chinese herbs help calm racing thoughts, irritability, sleep trouble, and nervous digestion
- Promotes relaxation without making you drowsy
- Supports focus and mental clarity as stress is reduced
Dosage: 2 tablets twice daily with food, or as professionally prescribed.
Size: 60 tablets or 120 tablets.
Do not use during pregnancy or breastfeeding. Herbal medicines may interact with some medications. Contains lactose, galactose, and a small amount of potassium (~12.9 mg per tablet). Always read the label and follow directions for use. Consult a healthcare professional if symptoms persist.
4. Eagle Tresos Activated B PluSe
Best for: burnout recovery & long-term stress resilience
View Eagle Tresos Activated B PluSe at Mr Vitamins
What it is: A practitioner-strength multivitamin providing activated B-vitamins along with key minerals, antioxidants, and amino acids to support the body when nutrient needs are increased due to stress or a busy lifestyle.
Key Ingredients (per tablet)
Activated B-Vitamins
A full range of activated B vitamins easier for the body to absorb and use. Essential for converting food into energy, supporting brain function, and maintaining a healthy nervous system - all of which are depleted faster during periods of high stress.
Antioxidant Vitamins - Vitamin C, Vitamin E, and Vitamin A
Vitamin C supports the immune system and helps manage physical stress; Vitamin E protects cells from oxidative damage; Vitamin A supports immune function, skin health, and vision. Together, these antioxidants maintain resilience under stress.
Minerals and Trace Elements - Magnesium, Zinc, Selenium & more
Magnesium helps calm the nervous system and supports muscle relaxation and healthy sleep. Zinc supports brain function, mood, and immune defence. Selenium supports thyroid health, helping regulate metabolism and energy levels.
Amino Acids & Supportive Nutrients - Taurine, Glutamine, Cysteine, and Bioflavonoids
Taurine supports brain function and may promote a calm, balanced mood. Glutamine supports gut health and immune function. Cysteine helps the body produce glutathione (a key antioxidant). Bromelain and citrus bioflavonoids support circulation and may help reduce inflammation.
Unlike some stress supplements, Tresos Activated B PluSe does not contain herbal adaptogens such as ashwagandha or holy basil. It focuses purely on high-strength nutritional support.
How it helps
- Supports energy levels and reduces fatigue
- Improves focus and concentration
- Supports sleep quality
- Maintains mood and stress resilience
- Supports immunity during stress
- Helps prevent burnout by supporting adrenal function
Dosage: 1 tablet daily with food, or as directed by a healthcare professional.
Size: 60 tablets or 150 tablets.
Vitamin B supplements may cause temporary bright yellow urine due to riboflavin - this is normal and harmless. Use caution if taking other B-vitamin supplements. Contains vitamin A - seek medical advice during pregnancy. Always read the label and follow directions for use. Consult a healthcare professional if symptoms persist.
How to Choose the Right Stress Supplement for You
- Identify your primary symptom - fatigue and low energy point toward activated B-vitamin formulas; anxiety, tension, and poor sleep point toward adaptogenic herbs.
- Consider your lifestyle - one-a-day convenience suits busy routines; higher-dose herbal formulas suit people with significant ongoing stress.
- Check for interactions - if you take sedatives, thyroid medication, or other prescription medicines, speak with your healthcare professional first.
- Choose practitioner-grade where possible - higher manufacturing standards mean more confidence in what's actually in each tablet or capsule.
- Give it time - herbal adaptogens often show effects within 1–2 weeks; nutritional formulas typically take 2-4 weeks to restore depleted levels.
- Supplements complement, not replace, the basics - sleep, nourishing food, movement, and moments of calm always make the biggest difference.
Frequently Asked Questions
What is the best type of supplement for stress?
The best supplement for stress depends on your needs. Activated B vitamins may suit people experiencing fatigue and low energy, while adaptogenic herbs such as ashwagandha or holy basil may help support a calmer stress response and mood balance. If you're unsure, our in-store naturopaths can help guide you.
Are stress supplements safe to take every day?
Many stress supplements are designed for daily use. However, the right product depends on the ingredients and your individual health needs. Always follow the label directions and seek professional advice if you are pregnant, breastfeeding, or taking medication.
Do stress supplements work straight away?
Some people notice benefits within a few days, particularly with calming herbal formulas. Nutritional formulas such as activated B vitamins may take a few weeks to restore nutrient levels and provide more noticeable improvements in energy and resilience.
Can I take stress supplements with other vitamins or medication?
Some ingredients may overlap with other supplements or interact with medication. If you are taking prescription medicine, thyroid medication, sedatives, or managing a health condition, consult a healthcare professional before starting a new supplement.
Bottom Line: Best Stress Support Supplements in Australia
The right stress supplement depends on how stress is showing up for you. Activated B-vitamin formulas can help support energy, focus, and recovery during periods of burnout, while adaptogenic herbal blends may assist with calming the nervous system, balancing cortisol, and easing tension.
Choose a practitioner-grade formula with clinically studied ingredients, follow the recommended dosage consistently, and give your body time to respond alongside healthy sleep, nutrition, and lifestyle habits.
Always follow the directions for use and check in with a healthcare professional if you have any medical conditions or are taking medication.
Resource List
[1] Activated B Stress - Herbs of Gold
[2][3] Frontiers in Nutrition - Randomised trial on Holixer™ (Holy Basil) effects on stress, mood, and sleep
[5] PMC - Systematic review and meta-analysis of B vitamin supplementation on depressive symptoms, anxiety, and stress
[8] MDPI Nutrients - Effects of Withania somnifera extract in chronically stressed adults
[9][10] NutraIngredients - Cognitive benefits of NooGandha ashwagandha ingredient
[11] PMC - Investigation into stress-relieving actions of ashwagandha extract (Shoden®)
General Disclaimer
This article is intended for general informational and educational purposes only. It does not constitute medical advice and is not a substitute for professional healthcare advice, diagnosis, or treatment. Always read the label and follow the directions for use. If symptoms persist, talk to your healthcare professional.
The information provided is not intended to diagnose, treat, cure, or prevent any disease or health condition. References to health benefits reflect the current state of published research on specific ingredients and are not claims made about any individual product. Individual results may vary.
The four supplements featured in this guide — Herbs of Gold Activated B Stress, Designs for Health TriGandha, Fusion Health Stress & Anxiety, and Eagle Tresos Activated B PluSe — are not listed complementary medicines (AUST L) and are not evaluated or endorsed by the Therapeutic Goods Administration (TGA) for specific health indications. Always verify current regulatory status on the TGA Australian Register of Therapeutic Goods (ARTG).
Designs for Health TriGandha is a practitioner-only product and is available exclusively to patients who have completed a consultation with the Mr Vitamins team.
Product selection and placement in this guide reflects the independent assessment of our practitioner and retail team, based on ingredient quality, clinical evidence, manufacturing standards, format, and value. No brand has paid for inclusion, placement, or editorial content. Prices are approximate recommended retail prices at the time of writing and are subject to change.
If you are pregnant, breastfeeding, taking prescription medications — particularly sedatives or thyroid-related medication — or have an existing health condition, consult a qualified healthcare professional before using any supplement. Keep all supplements out of reach of children. Vitamin and mineral supplements should not replace a balanced diet.
Content reviewed by Christina Hanley (Bachelor of Nutritional Medicine). Last reviewed: May 2026. © Mr Vitamins. All rights reserved.
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